孟 和   职称: 教授 所属学科：畜牧学 研究方向: (1)动物基因组学和分子育种 (2)动物宿主-肠道微生物互作 电话/传真：021-34206146 电子信箱: menghe@sjtu.edu.cn 联系地址：上海市东川路800号，新葡的京集团8814 新葡的京集团88143-301室

 

教育背景

1982.09-1986.07 内蒙古农业大学, 畜牧专业,学士学位；1986.09-1989.07 内蒙古农业大学, 动物遗传育种,硕士学位；1999.09-2002.07 东北农业大学，动物遗传育种，博士学位；2002.12-2004.12 新葡的京集团8814，生物医学工程博士后流动站；2007.05-2008.02 美国弗吉尼亚理工大学（VT），访问学者；2010.08-2010.09 荷兰国家应用科学组织（TNO），访问学者；2011.08-2011.11 美国弗吉尼亚理工大学（VT），访问学者。

世界家禽学会中国分会会员，中国畜牧兽医学会家禽学分会理事，上海市细胞生物学学会理事，中国遗传学会会员，中国细胞生物学学会会员，中国生物信息学会会员，中国农业生物技术学会会员，上海畜牧兽医学会理事，上海市畜禽种质资源保护和利用委员会委员。

长期主讲《生命科学发展史》、《动物基因组学》、《动物生产学》等课程。

先后主持国家高技术研究发展计划（863计划）重点项目、国家自然基金面上项目、中国博士后科学基金，上海市自然基金，上海市科技兴农重点攻关项目等各级各类科研项目15项。

 

主要成果： 

主讲课程《生命科学发展史》获评“国家精品在线开放课程”（2018年）、新葡的京集团8814 “通识核心优质课程”（2018年）、上海市教委高校在线课程建设项目（2015年）、新葡的京集团8814首批MOOC课程建设项目（2013年）、上海市教委重点课程立项建设项目（2011年）、新葡的京集团8814首批通识教育核心课程建设项目（2008年）。发表“在实践中学习通识教育”等多篇教学研究论文。2009至今被聘为新葡的京集团8814通识教育核心课程专家。

曾先后荣获新葡的京集团8814 “教书育人奖”二等奖（2018年）、新葡的京集团8814“唐立新教学名师奖” （2018年）、新葡的京集团8814“凯原十佳教师”（2015年）、新葡的京集团8814优秀教师一等奖（2014年）、新葡的京集团8814通识教育贡献奖一等奖（2013年）、新葡的京集团8814教学成果二等奖（2008年，2016年）等多项表彰奖励。

   在Nature Communications、Molecular ﹠ Cellular Proteomics、Animal Genetics、Applied and Environmental Microbiology、Frontiers in Microbiology、Genetics Selection Evolution、Scientific Reports、Current Microbiology、Poultry Science、Journal of Dairy Science、Journal of Bacteriology、Plos one、遗传学报、动物学报、微生物学报、中国家禽等专业期刊上发表学术论文70余篇。

世界首例双峰驼基因组计划发起人和主要完成人，成果2012年发表在Nature子刊《Nature Communications》（DOI: 10.1038/ncomms2192）。合作研究项目"益生菌L.caseiZhang的筛选及基因组学和蛋白质组学研究" 获2009年内蒙古自治区自然科学奖1等奖（排名第2）。

 

近期代表性论文：

1. Lu Xiao, Chuan He, Lingxiao Luo, Kaixuan Yang, Lingyu Yang, Ke Xu, Yuming Zheng, Caiju Gu, Qizhong Huang*, He Meng *. Genome-wide association study identified genes in the response to Salmonella pullorum infection in chickens. Anim Genet. 2019 Apr 24. doi: 10.1111/age.12787.

2. Eugene Rosenberg, Ilana Zilber-Rosenberg, He Meng (Interpreter). 2018. The hologenome concept: human, animal and plant microbiota. Beijing: Science Press.

3. Jing Dong, Chuan He, Zhibing Wang, Yanqing Li, Shanshan Li, Lin Tao, Jiebo Chen, Donghua Li, Fenxia Yang, Naibin Li, Quan Zhang, Li Zhang, Guangqin Wang, Fisayo Akinyemi, He Meng*  and Bingwang Du*. A novel deletion in KRT75L4 mediates the frizzle trait in a Chinese indigenous chicken. Genet Sel Evol. 2018,50(1):68. doi: 10.1186/s12711-018-0441-7.

4. Lingyu Yang, Chao Liu, Wenjing Zhao, Chuan He, Jinmei Ding, Ronghua Dai, Ke Xu, Lu Xiao, Lingxiao Luo, Shuyun Liu, Wei Li*, He Meng*. Impaired Autophagy in Intestinal Epithelial Cells Alters Gut Microbiota and Host Immune Responses. Appl Environ Microbiol. 2018 Aug 31;84(18). pii: e00880-18. doi: 10.1128/AEM.00880-18.

5. Li Xu,Liyan Ding,Manyu Li,Zhenhua Guo,Xin Li,Jinyan Sun,Jingming Zhou,Yanzhong Feng,Haijuan He,Hongda Wu,Xiangkui Fu,and He Meng*.Gut microbiota correlates with fiber and apparent nutrients digestion in goose. Poultry Science. 2018, doi: 10.3382/ps/pey249

6. Lingyu Yang, Rongliang Guan,Yixiang Shi, Jinmei Ding, Ronghua Dai, Weixing Ye, Ke Xu, Yu Chen,  Li Shen,Yanyan Liu, Fangmei Ding, Chuan He, He Meng*. Comparative genome and transcriptome analysis reveals the medicinal basis and environmental adaptation of artificially cultivated Taiwanofungus camphoratus. Mycological Progress. 2018, 17(8): 871–883

7. Jinmei Ding, Ronghua Dai, Lingyu Yang, Chuan He, Ke Xu, Shuyun Liu,Wenjing Zhao, Lu Xiao, Lingxiao Luo, Yan Zhang* and He Meng*.Inheritance and Establishment of Gut Microbiota in Chickens. Frontiers in Microbiology. 2017,8:1967. doi: 10.3389/fmicb.2017.01967

8. Lingyu Yang, Shuyun Liu, Jinmei Ding, Ronghua Dai , Chuan He, Ke Xu,Christa F. Honaker, Yan Zhang*, Paul Siegel * and He Meng*. Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity. Frontiers in Microbiology. 2017, 8:1243. doi: 10.3389/fmicb.2017.01243.

9. Chuan He, Yongcan Chen1, Kaixuan Yang, Zhengxiao Zhai1, Wenjing Zhao,Shuyun Liu, Jinmei Ding, Ronghua Dai, Lingyu Yang, Ke Xu, Zhenxiang Zhou, Caiju Gu, Qizhong Huang*, He Meng*.

10. Genetic pattern and gene localization of polydactyly in Beijing fatty chicken. PLoS One. 2017, 12(5): e0176113.

11. Jinmei Ding, Lele Zhao, Lifeng Wang, Wenjing Zhao, Zhengxiao Zhai, Li Leng, Yuxiang Wang,Chuan He, Yan Zhang, Heping Zhang, Hui Li and He Meng*. Divergent selection‑induced obesity alters the composition and functional pathways of chicken gut microbiota. Genetics Selection Evolution. 2016, 48:93 DOI 10.1186/s12711-016-0270-5

12. Ronghua Dai, Yu Fang, Wenjing Zhao, Shuyun Liu, Jinmei Ding, Ke Xu, Lingyu Yang,Chuan He, Fangmei Ding and He Meng*.Identification of alleles and genotypes of beta-casein with DNA sequencing analysis in Chinese Holstein cow. Journal of Dairy Research.2016, 83:312–316

13. Guangliang Gao, Xianzhi Zhao, Qin Li, Chuan He, Wenjing Zhao, Shuyun Liu, Jinmei Ding, Weixing Ye, Jun Wang, Ye Chen, Haiwei Wang, Jing Li, Yi Luo, Jian Su, Yong Huang, Zuohua Liu, Ronghua Dai, Yixiang Shi, He Meng*, Qigui Wang*. Genome and metagenome reveals adaptive evolution of host and interaction with gut microbiota in goose. Scientific Reports. 2016,6:32961 | DOI: 10.1038/srep32961

14. Long Liu, Xing Zhao, Xiaoxian Sun, Lili Xia, Qianqian Wang, Biao Yang, Yihui Zhang, Sean Montgomery, He Meng, Tuoyu Geng*, and Daoqing Gong*. Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System. Scientific Reports. 2016, 6:31763 | DOI: 10.1038/srep31763

15. Shuyun Liu, Lele Zhao, Zhengxiao Zhai, Wenjing Zhao, Jinmei Ding. Ronghua Dai, Tao Sun, He Meng*. Porcine Epidemic Diarrhea Virus Infection Induced the Unbalance of Gut Microbiota in Piglets. Current Microbiology. 2015, DOI 10.1007/s00284-015-0895-6.

16. Wenjing Zhao, Yapeng Wang, Shuyun Liu, Jiaojiao Huang, Zhengxiao Zhai, Chuan He, Jinmei Ding, Jun Wang, Huijuan Wang, Weibing Fan, Jianguo Zhao, He Meng*. The Dynamic Distribution of Porcine Microbiota across Different Ages and Gastrointestinal Tract Segments. PLoS One. 2015, 10(2):e0117441.

17. Zhengxiao Zhai, Wenjing Zhao, Chuan He, Kaixuan Yang, Linlin Tang, Shuyun Liu, Yan Zhang, Qizhong Huang and He Meng*. SNP discovery and genotyping using restriction-site-associated DNA sequencing in chickens. Animal Genetics, 2015, 46(2):216-9, doi: 10.1111/age.12250.

18. He Meng*., Yan Zhang *., Lele Zhao , Wenjing Zhao , Chuan He , Christa F. Honaker ,Zhengxiao Zhai , Zikui Sun , Paul B. Siegel*. Body Weight Selection Affects Quantitative Genetic Correlated Responses in Gut Microbiota. PLoS One. 2014 Mar 7;9(3):e89862. doi: 10.1371/journal. Pone. 0089862.

19. Na Qiao , Qi Liua, He Meng* , Dayun Zhao*.Haemolytic activity and adjuvant effect of soyasaponins and some of their derivatives on the immune responses to ovalbumin in mice. International Immunopharmacology.2014,18: 333–339

20. Jinlong Huang, Yiping Zhao, Dongyi Bai, Wunierfu Shiraigol1, Bei Li1, Lihua Yang,Jing Wu, Wuyundalai Bao, Xiujuan Ren, Burenqiqige Jin, Qinan Zhao, Anaer Li,Sarula Bao, Wuyingga Bao, Zhencun Xing, Aoruga An, Yahan Gao, Ruiyuan Wei,Yirugeletu Bao, Taoketao Bao, Haige Han, Haitang Bai, Yanqing Bao, Yuhong Zhang,Dorjsuren Daidiikhuu, Wenjing Zhao, Shuyun Liu, Jinmei Ding, Weixing Ye, Fangmei Ding, Zikui Sun, Yixiang Shi, Yan Zhang*, He Meng *& Manglai Dugarjaviin*. Donkey genome and insight intothe imprinting of fast karyotype evolution. Scientific Reports.2015, 5:14106, DOI: 10.1038/srep14106.

21. Jinlong Huang, Yiping Zhao, Wunierfu Shiraigol, Bei Li, Dongyi Bai, Weixing Ye,Dorjsuren Daidiikhuu, Lihua Yang, Burenqiqige Jin, Qinan Zhao, Yahan Gao, Jing Wu,Wuyundalai Bao, Anaer Li, Yuhong Zhang, Haige Han, Haitang Bai, Yanqing Bao, Lele Zhao,Zhengxiao Zhai, Wenjing Zhao, Zikui Sun, Yan Zhang, He Meng & Manglai Dugarjaviin*. Analysis of horse genomes providesinsight into the diversification andadaptive evolution of karyotype. Scientific Reports. 2014, 4 : 4958, DOI: 10.1038/srep04958.

22. Lele Zhao, Gang Wang, Paul Siegel, Chuan He, Hezhong Wang, Wenjing Zhao, Zhengxiao Zhai, Fengwei Tian, Jianxin Zhao, Hao Zhang, Zikui Sun, Wei Chen, Yan Zhang& He Meng*. Quantitative Genetic Background of the Host Influences Gut Microbiomes in Chickens. Scientific Reports. 2013, 3:1163. doi:10.1038/srep01163

23. Jirimutu, Zhen Wang, Guohui Ding, Gangliang Chen, Yamin Sun, Zhihong Sun, Heping Zhang, Lei Wang, Surong Hasi, Yan Zhang, Jianmei Li, Yixiang Shi, Ze Xu, Chuan He, Siriguleng Yu, Shengdi Li, Wenbin Zhang, Mijiddorj Batmunkh, Batsukh Ts, Narenbatu, Unierhu, Shirzana Bat-Ireedui, Hongwei Gao, Banzragch Baysgalan, Qing Li, Zhiling Jia, Turigenbayila, Subudenggerile, Narenmanduhu, Zhaoxia Wang, Juan Wang, Lei Pan, Yongcan Chen, Yaichil Ganerdene, Dabxilt, Erdemt, Altansha, Altansukh, Tuya Liu, Minhui Cao, Aruuntsever, Bayart, Hosblig, Fei He, A Zha-ti, Guangyong Zheng, Feng Qiu, Zikui Sun, Lele Zhao, Wenjing Zhao, Baohong Liu, Chao Li, Yunqin Chen, Xiaoyan Tang, Chunyan Guo, Wei Liu, Liang Ming, Temuulen, Aiying Cui, Yi Li, Junhui Gao, Jing Li, Wurentaodi, Shen Niu, Tao Sun, Zhengxiao Zhai, Min Zhang, Chen Chen, Tunteg Baldan, Tuman Bayaer, Yixue Li & He Meng *. Genome sequences of wild and domestic bactrian camels. Nature Communications. 2012 ,3:1202. doi: 10.1038/ncomms2192.

24. Kaixuan Yang, Yongcan Chen, Caiju Gu, Zhenxiang Zhou,Chuan He, Linlin Tang, Shiyu Li, Lele Zhao, He Meng*and Qizhong Huang*. Polydactyly mutation is linked to chromosome 2p region in Beijing fatty chicken. Animal Genetics.2012, doi: 10.1111/j.1365-2052.2012.02369.x

 

代表性专著或译著：

1. 《共生总基因组：人类、动物、植物及其微生物区系》 [以色列] E.罗森伯格，I.齐博尔-罗森伯格 著，孟和 译，科学出版社 ISBN：9787030599414，2019-01-01出版。
2. 《农业生物实验基础教程》，上海科技文献出版社，孟和 沈明泉 主编，2006.9（ISBN: 7543930099）