PI组长：
       唐克轩  特聘教授

组员：
       苗志奇 赵静雅  王玉亮 潘琪芳 王贵荣 黎凌

研究方向：
       植物合成生物学和代谢工程

主要研究领域：

（1）植物代谢调控与代谢工程

（2）植物生物技术与生物反应器

（3）合成生物学

主要从事植物代谢调控、基因工程和合成生物学、高科技天然营养健康保健产品以及生物技术相关领域的研究和产品开发。目前研究组拥有包括由教授、副教授和研究生等近40人组成的知识结构合理和人才稳定的高科技创新研究团队。

PI研究组代表性成果：

1、主要研究项目：

1）基于植物底盘的药用植物活性成分研究及其应用（国家合成生物学专项2018YFA0900604，2019年-2024年，594万元）

2）Identification and functional characterization of putative enzymes involved in the artemisinin biosynthesis from Artemisia annua（Bill & Melinda Gates Foundation OPP1199872，2018年-2019年，75万美元）

3）抗蚜虫转基因小麦新品系培（国家转基因重大专项2016ZX08002001-006，2016年-2020年，502万元)

4）植物代谢产物生物反应器产品研发（国家863计划重大项目2011AA100605，2011年-2016年，861万元)

5）抗蚜虫转基因小麦新品系和新种质创制（国家转基因重大专项2008ZX08002-001，2011ZX08002-001，2008年-2012年，590万元)

6）青蒿药物植物产品关键技术研究与应用（上海市科委重点项目08391911800，2008年-2011年，100万元）

7）农作物特殊营养品质的代谢工程(国家973计划项目2007CB108805,2007年-2011年，565万元)

2、成果专利与奖励：

申请或授权中国国家发明专利160余项，其中授权发明专利50余项。申请国际专利2项：

1) 降血脂的中药组合物及其制备方法，发明人：唐克轩，王玉亮，辛海量，唐罗欧。国际专利申请号：PCT/CN2010/070921，申请日：2010年9月30日，公开日：20100309，Publication number： WO2010/108408 （COMPOSITION OF TRADITIONAL CHINESE MEDICINE FOR REDUCING BLOOD FAT AND PREPARATION METHOD THEREOF），美国专利公开日：2012年2月16日，公开号：US 2012/0041058

2) 青蒿秸秆的综合利用方法及其用途，发明人：唐克轩，王玉亮，孙小芬，唐罗欧。国际专利申请号:PCT/CN2013/077543，申请日：2013年6月20日。

以第一完成人获得2009年高等教育上海市级教学成果二等奖和2014年上海市技术发明二等奖。

3、代表论著：

1) Ya-Nan Ma, Dong-Bei Xu, Ling Li, Fei Zhang, Xue-Qing Fu, Qian Shen, Xue-Ying Lyu, Zhang-Kuanyu Wu, Qi-Fang Pan, Pu Shi, Xiao-Long Hao, Ting-Xiang Yan, Ming-Hui Chen, Pin Liu, Qian He, Li-Hui Xie, Yi-Jun Zhong, Yue-Li Tang, Jing-Ya Zhao, Li-Da Zhang, Xiao-Fen Sun, and Ke-Xuan Tang (2018). Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua. Sciences advances 4(11): eaas9357

2)Shen, Qian; Zhang, Lida; Liao, Zhihua; Wang, Shengyue; Yan, Tingxiang; Shi, Pu; Liu, Meng; Fu, Xueqing; Pan, Qifang; Wang, Yuliang; Lv, Zongyou; Lu, Xu; Zhang, Fangyuan; Jiang, Weimin; Ma, Yanan; Chen, Minghui; Hao, Xiaolong; Li, Ling; Tang, Yueli; Lv, Gang; Zhou, Yan; Sun, Xiaofen; Brodelius, Peter E.; Rose, Jocelyn K. C.; Tang, Kexuan (2018). The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis. MOLECULAR PLANT 11(6):776-788.

3)Yan, Tingxiang; Li, Ling; Xie, Lihui; Chen, Minghui; Shen, Qian; Pan, Qifang; Fu, Xueqing; Shi, Pu; Tang, Yueli; Huang, Huayi; Huang, Yiwen; Huang, Youran; Tang, Kexuan (2018). A novel HD-ZIP IV/MIXTA complex promotes glandular trichome initiation and cuticle development in Artemisia annua. New Phytologist 218(2):567-578.

4) Shi, Pu; Fu, Xueqing; Shen, Qian; Liu, Meng; Pan, Qifang; Tang, Yueli; Jiang, Weimin; Lv, Zongyou; Yan, Tingxiang; Ma, Yanan; Chen, Minghui; Hao, Xiaolong; Liu, Pin; Li, Ling; Sun, Xiaofen; Tang, Kexuan (2018). The roles of AaMIXTA1 in regulating the initiation of glandular trichomes and cuticle biosynthesis in Artemisia annua. New Phytologist 217(1):261-276.

5)Yan, T., Chen, M., Shen, Q., Li, L., Fu, X., Pan, Q., Tang, Y., Shi, P., Lv, Z., Jiang, W., Ma, Y., Hao, X., Sun, X. and Tang, K. (2017). HOMEODOMAIN PROTEIN 1 is required for jasmonate-mediated glandular trichome initiation in Artemisia annua. New Phytologist 213(3):1145-1155.

6)Lv, Z., Wang, S., Zhang, F., Chen, L., Pan, Q., Hao, X., Fu, X., Li, L., Sun, X. and Tang, K. (2016). Overexpression of a novel NAC domain-containing transcription factor (AaNAC1) enhances the content of artemisinin and increases tolerance to drought and Botrytis cinerea in Artemisia annua. Plant and Cell Physiology 57(9):1961-1971.

7)Tang, K., Shen, Q., Lu X. and Zhang, F. (2016). Improving artemisinin content in Artemisia annua by transcription factor regulation. Science (supplement): 48-51.

8)Shen, Q., Lu, X., Yan, T., Fu, X., Lv, Z., Zhang, F., Pan, Q., Wang, G., Sun, X. and Tang, K. (2016). The jasmonate-responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis in Artemisia annua. New Phytologist 210: 1269-1281.

9)Lv, Z., Zhang, F., Pan, Q., Fu, X., Jiang, W., Shen, Q., Yan, T., Shi, P., Lu, X., Sun, X. and Tang, K. (2016). Branch Pathway Blocking in Artemisia annua is a Useful Method for Obtaining High Yield Artemisinin. Plant and Cell Physiology 57(3): 588-602.

10)Moses, T., Pollier, J., Shen, Q., Soetaert, S., Reed, J., Erffelinck, M., Van Nieuwerburgh, F.C.W., Bossche, R.V., Osbourn, A., Thevelein, J.M., Deforce, D., Tang, K. and Goossens, A. (2015). OSC2 and CYP716A14v2 Catalyze the Biosynthesis of Triterpenoids for the Cuticle of Aerial Organs of Artemisia annua. Plant Cell. 27(1), 286-301

11)Zhang, F., Fu, X., Lv, Z., Lu, X., Shen, Q., Zhang, L., Zhu, M., Wang, G., Sun, X., Liao, Z. and Tang K. (2015). AabZIP1, Connects Abscisic Acid Signaling with Artemisinin Biosynthesis in Artemisia annua. Molecular Plant 8: 163-175.

8)Lu X, Zhang F, Shen Q, Jiang W, Pan Q, Lv Z, Yan, T., Fu, X., Wang, Y., Qian, H. and Tang, K. (2014) Overexpression of Allene Oxide Cyclase Improves the Biosynthesis of Artemisinin in Artemisia annua L.. PLoS ONE 9(3): e91741.

12)Lu, X., Zhang, L., Zhang, F., Jiang, W., Shen, Q., Zhang, L., Lv, Z., Wang, G. and Tang, K. (2013). AaORA, a trichome-specific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea. New Phytologist 198: 1191-1202.

13)Pan, Q., Wang, Q., Yuan, F., Xing, S., Zhao, J., Choi, Y., Verpoorte, R., Tian, Y., Wang, G. and Tang, K. (2012). Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. PLoS ONE 7(8): e43038.

14)Zhang, F., Zuo, K., Zhang, J., Liu, X., Zhang, L., Sun, X. and Tang, K. (2010). An L1 box binding protein, GbML1, interacts with GbMYB25 to control cotton fibre development. Journal of Experimental Botany 61(13):3599–3613.

15)Liu, X., Zuo, K., Xu, J., Li, Y., Zhang, F., Yao, H., Wang, Y., Chen, Y., Qiu, C., Sun, X. and Tang K. (2010). Functional analysis of GbAGL1, a D-lineage gene from cotton (Gossypium barbadense). Journal of Experimental Botany 61(4): 1193-1203

16)Zhang, L., Ding, R., Chai, Y., Bonfill, M., Moyano, E., Oksman-Caldentey, K-M., Xu, T., Pi, Y., Wang, Z., Zhang, H., Kai, G., Liao, Z., Sun, X., and Tang, K. (2004). Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures. Proceedings of the National Academy of Sciences USA 101(17): 6786-6791.