报告题目：双组份系统调控肠炎沙门氏菌耐药性形成的分子机制及其靶向天然抑菌物质筛选

报告摘要：

 肠炎沙门氏菌是常见的食源性致病菌，其耐药率逐年攀升、耐药谱不断变宽，给食品安全带来严峻挑战。双组份系统（TCS）是细菌中重要的调控因子，它由组氨酸感应激酶和响应调控蛋白两个元件组成，通过磷酸化激活方式来调节基因转录。早期的研究表明，TCS广泛参与多个生物学过程，与细菌的毒力、趋化以及氧化应激密切相关。最近的研究发现，TCS在沙门氏菌耐药性形成中也发挥着重要调控作用，因此被认为是高效防控耐药菌的潜在靶点。报告人主要介绍TCS的基本结构和功能，TCS在调控肠炎沙门氏菌耐药性形成过程中的关键作用，并探讨靶向TCS在联合抗菌中的潜在可能。

报告摘要：

胡梦君博士于2023年在新葡的京集团8814获得博士学位，现在园艺学流动站从事博士后研究工作。长期聚焦微生物学、分子生物学及食品科学，主持中国博士后科学基金一项，共发表SCI论文12篇，其中第一作者文章5篇，包括mBio，mSphere，Journal of Agricultural and Food Chemistry，Clinical & Experimental Allergy等。

【所在学科研究组研究方向】：

所在研究组主要致力于食品安全与食源性细菌分子生态方面的研究，主要包括：1）食源性致病微生物分子检测技术； 2）食源性致病菌基因功能分析体系；3）沙门氏菌对食品加工逆境的应答机制； 4）沙门氏菌耐药性形成的分子调控机制；5）基于天然产物的致病菌高效防控技术。

【代表性著作】

1. Mengjun Hu, Yuyan Zhang, Xiaozhen Huang, Mu He, Jinyu Zhu, Zengfeng Zhang, Yan Cui, Shoukui He, Xianming Shi. 2023. PhoPQ regulates quinolone and cephalosporin resistance formation in Salmonella Enteritidis at the transcriptional level. mBio, 14:e0339522.

2. Mengjun Hu, Xiaozhen Huang, Xuebin Xu, Zengfeng Zhang, Shoukui He, Jinyu Zhu, Hong Liu, Xianming Shi. 2022. Characterization of the role of two-component systems in antibiotic resistance formation in Salmonella enterica serovar Enteritidis. mSphere, 7:e0038322.

3. Xiaozhen Huang, Mengjun Hu, Xiujuan Zhou, Yanhong Liu, Chunlei Shi, and Xianming Shi. 2020. Role of yoaE gene regulated by CpxR in the survival of Salmonella enterica serovar Enteritidis in antibacterial egg white. mSphere, 5: e00638-19. 

ACADEMIC SALON (LIV)

SPEAKER: Mengjun Hu

Post doctor, Ph.D.

Department of Food Science & Engineering, SAB

TIME：12:40-14:00 June 19, 2024 (Wed)

VENUE：Room 104, Building B, SAB

ORGANIZER：Office of Discipline and Science & Technology, SAB

Young Teachers Association, SAB

TITLE： Molecular mechanism of antibiotic resistance formation in Salmonella Enteritidis regulated by a two-component system and screening of its targeted natural antimicrobial compounds

ABSTRACT：

Salmonella Enteritidis is an important foodborne pathogen, which often possesses antibiotic resistance of yearly increasing prevalence and broad spectrum, posing a threat to food safety. The two-component systems (TCSs) consist of a sensor histidine kinase and a response regulator, which regulate gene transcription by activating phosphorylation. Early studies have shown that TCSs are widely involved in several biological processes of bacteria, including virulence, chemotaxis and oxidative stress. Recent studies have found that TCSs also play an important regulatory role in antibiotic resistance formation in Salmonella. Thus, it is considered as a potential target for controlling drug-resistance bacteria. In the current presentation, the presenter will briefly introduce the basic background of TCSs, the key function of TCSs in antibiotic resistance formation, and explore the possibility of targeting TCSs in combined antibacterial.